Just thought that following on from Kizzie's discussion on psychological reactions to drugs. It might be helpful to me and others to start a discussion about physical reactions
I've always had issues with drugs but as I've got older there are more and more drugs and also some substances that I'm very intolerant to.
Just to give some examples:
Codeine, just 30mg, half what I was told to take had me rushed to A&E in an ambulance with suppressed breathing and lowered heart rate. Told to never touch again not even an over the counter small amount as it's too dangerous.
TARAVID, Ofloxacin, Penecillin, (all antibiotics) left me with skin rash.
Tagamet (cimetidine) for GERD not sure what the US equivalent left me with a swollen liver and needing a full body scan to ensure no permanent damage to other organs.
Anti inflammatory drugs give me a gastric reaction.
Statins left me feeling generally unwell, with dizziness and muscle pain.
Gabapentin led to very fast weight gain, I'm talking 20lbs in 6 weeks! Plus insomnia and feeling nauseous all the time.
Citalopram (and boy did I need that at the time) left me with a gastric reaction as in severe indigestion, bloating and stomach pain
Tramadol - 50mg dropped my oxygen levels so low I passed out for several hours.
Pregabalin - Cold sweat and fainting.
An anaesthetist warned me he believes I'm an ultra-rapid metaboliser. Which means any drug metabolised through the liver can cause me problems or worse may have no effect at all. He diagnosed that from my reaction to Codeine. A normal reaction is to metabolise 20% of codeine to Morphine through the liver. But ultra rapid metabolisers (like me) metabolise 70%+ into a morphine, hence my extreme reaction. It can kill! I have a similar reaction to all painkillers. But the way we metabolise drugs is a genetic issue
But I believe that trauma may have over sensitised my system too.
I also have MS, Epilepsy (as part of MS), osteoarthritis so some of these drugs may have helped. I also have GERD so a very sensitive tummy too.
My osteopath believes that my whole system is ultra sensitive because of the trauma. But especially the sympathetic and parasympathetic nervous systems, hence the 'brain' in the tummy is ultra reactive. It's a nightmare negotiating drugs as I get older.
I even 'reacted' to digestive enzymes which are supposed to help your tummy. Plus food sensitivities like lactose etc.
Sorry but it's a long list.
Does anyone else recognise this journey? Is this all down to genetics or can there be a trauma link to physical reactions.
I want to say yes as the ACE study points to physical illness so why not physical reactions? I'd be really interested in others experience with this.
I've always had issues with drugs but as I've got older there are more and more drugs and also some substances that I'm very intolerant to.
Just to give some examples:
Codeine, just 30mg, half what I was told to take had me rushed to A&E in an ambulance with suppressed breathing and lowered heart rate. Told to never touch again not even an over the counter small amount as it's too dangerous.
TARAVID, Ofloxacin, Penecillin, (all antibiotics) left me with skin rash.
Tagamet (cimetidine) for GERD not sure what the US equivalent left me with a swollen liver and needing a full body scan to ensure no permanent damage to other organs.
Anti inflammatory drugs give me a gastric reaction.
Statins left me feeling generally unwell, with dizziness and muscle pain.
Gabapentin led to very fast weight gain, I'm talking 20lbs in 6 weeks! Plus insomnia and feeling nauseous all the time.
Citalopram (and boy did I need that at the time) left me with a gastric reaction as in severe indigestion, bloating and stomach pain
Tramadol - 50mg dropped my oxygen levels so low I passed out for several hours.
Pregabalin - Cold sweat and fainting.
An anaesthetist warned me he believes I'm an ultra-rapid metaboliser. Which means any drug metabolised through the liver can cause me problems or worse may have no effect at all. He diagnosed that from my reaction to Codeine. A normal reaction is to metabolise 20% of codeine to Morphine through the liver. But ultra rapid metabolisers (like me) metabolise 70%+ into a morphine, hence my extreme reaction. It can kill! I have a similar reaction to all painkillers. But the way we metabolise drugs is a genetic issue
But I believe that trauma may have over sensitised my system too.
I also have MS, Epilepsy (as part of MS), osteoarthritis so some of these drugs may have helped. I also have GERD so a very sensitive tummy too.
My osteopath believes that my whole system is ultra sensitive because of the trauma. But especially the sympathetic and parasympathetic nervous systems, hence the 'brain' in the tummy is ultra reactive. It's a nightmare negotiating drugs as I get older.
I even 'reacted' to digestive enzymes which are supposed to help your tummy. Plus food sensitivities like lactose etc.
Sorry but it's a long list.
Does anyone else recognise this journey? Is this all down to genetics or can there be a trauma link to physical reactions.
I want to say yes as the ACE study points to physical illness so why not physical reactions? I'd be really interested in others experience with this.