DOSULEPIN MYLAN - I think I'm a Zebra

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Nab

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DOSULEPIN MYLAN - I think I'm a Zebra
« on: December 17, 2021, 11:29:45 AM »
 :heythere:
Hello

I've been learning a lot about my brain and the ways it has been bent, why it possibly works the way it does and how the meds work.  It's helped me to accept the differences and understand that it's not my fault.

I take Dosulepin Mylan 25mg/day...with near immediate effect. Within an hour of taking it. It doesn't make me sleepy - It wakes me up! While I have bradycardia, my BP is raised a smidgen and a slight tachycardic reaction which actually raises my HR to "normal" levels. I have a pacemaker that looks after the bradycardia should my BP fall below 50pbm and the bottom lead paces the Ventricle to pump 100% of the time because there's a complete heart block/3rd degree AV block.

While my GP prescribed me 1 capsule twice a day for two weeks, the increase to two capsules twice a day....The first day on the two capsules spread across the day had me bouncing off the walls at 3am...cos it doesn't make me sleepy  :Idunno: I've asked if I can just take one a day and I really need to get him to chat the Hospital GP Liaison and ask about the effect on me and how taking 50mg in the morning might suit me better. I have taken 75mg/day in the past...but I have recently recovered a repressed memory and it's possible that the physiology of my brain has improved with the reintegration of the memory.
Ref: https://pubmed.ncbi.nlm.nih.gov/19301997/

It would appear that I'm a Zebra [exotic case] ...not a horse.
I haven't seen a specialist yet....my GP didn't refer met to the specialist when I asked for it   :pissed: and I have been unpacking this new cptsd episode on my own. It's been a "fun" ride. :blink:  My case has yet to be triaged.   :blink:

Does anyone else use this stuff with a different than normal effect?
For me it works really well and almost immediately.
https://go.drugbank.com/drugs/DB09167




« Last Edit: December 17, 2021, 11:33:59 AM by Nab »

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Kizzie

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Re: DOSULEPIN MYLAN - I think I'm a Zebra
« Reply #1 on: December 18, 2021, 04:32:02 PM »
I definitely do Nab and I've been wondering just how many of us with CPTSD that have this issue - the Zebra response that is.  I think it's called "paradoxical reaction" - https://pubmed.ncbi.nlm.nih.gov/22272687/

I have it with quite a few meds and I know of another member (not on much anymore) who is the same. It's not something we've talked about a lot here but I suspect there are more of us than we know.  It stands to reason really that with the changes to our nervous systems, etc., we don't react the same way to some meds, which ones though is a big question.

Mine include: contraceptive pills, Gravol, over-the-counter meds like Gravol, Robaxecet, nighttime cold meds; steroids - one of my meds for cancer; anxiety meds like Diazepam; Ambien (sleeping pill); and Ozempic (diabetes/weight loss meds).  My reactions range from agitation and restlessness to anxiety attacks. 

When I had the steroids in my cancer cocktail I climbed to walls for hours they jazzed me up that much which sounds a lot like what you experience with the Dosulepin.  The oncology team finally relented and stopped adding it and I was fine for the rest of the treatments.

You're not alone in this and I'm fairly certain a lot of us are Zebras so hope this helps validate your reaction. Maybe it's time to explore this and collect some info about it so we have a better idea about meds and CPTSD. 

Tks for starting this thread  :)

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Nab

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Re: DOSULEPIN MYLAN - I think I'm a Zebra
« Reply #2 on: December 19, 2021, 11:02:34 PM »
Oh.. thank goodness. I hoped I wasn't alone in this.

Fluoxetine doesn't do much. Takes the edge off but no more than St. John's Wort.

Dosulepin though:
The 75Mg years ago worked quickly too. Within 1/2 an hr there was quite a dramatic "shift" ... Like the start of a tipsy effect but waking me up. Spooky.

The 25mg isn't so dramatic but in the same time frame.

Yes. This does require more research. I'm hoping to ask a specialist some questions about this in the new year. 

We should make a list.
« Last Edit: December 19, 2021, 11:07:26 PM by Nab »

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Kizzie

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Re: DOSULEPIN MYLAN - I think I'm a Zebra
« Reply #3 on: December 21, 2021, 05:22:53 PM »
I like the idea of a list or at least a thread about meds members have reacted to. I'll start a stocky thread (stays at the top) so we can collect info over time.

Forgot caffeine on my list.