After talking about the genetic link, I was interested in looking more into the info I got three years ago. You can take your raw data from 23andme and upload it into various other genetic apps/programs which sort and categorize it for you. I used Promethase and Genetic Genie.
https://promethease.com/
https://geneticgenie.org/Promethase is not that user friendly but gives all the breakdowns and Genetic Genie gives you your methylation and detoxification panels. I think I need an intermediate to advanced organic chemistry course here, but am trying to make headway. Also, I think even if you have one gene susceptible to something doesn't mean there's other genetic factors or the right environment for it to be expressed.
I thought I had an issue with methylation and coming back it seems that even though I don't have red, there's a lot of yellow. As I understand, a lot of the methylation process is involved in the manufacturing of neurotransmitters, elimination of hormones etc. Certain bacteria like H Pylori (which I had) can cause "hypermethylation" where it uses up all the folate/methyl donors that your body needs for the methylation cycle, causing detox issues. Low B12 and folate can be a sign of this.
MTHFR C677T is the "big one" that can cause "impaired function of the enzyme can cause or contribute to conditions such as Autism, Chronic Fatigue Syndrome, Fibromyalgia, Miscarriages, IBS, many birth defects, Multiple Sclerosis, Alzheimer's, Bipolar Disorder, blood clots, Stroke, Chemical Sensitivity, and many other conditions." There is also a link between this gene and the development of a major depressive disorder later in life. Apparently, according to the Dr. Axe link, certain antibiotics can also deplete low folate levels and interfere with the methylation cycle further.
https://draxe.com/health/mthfr-mutation/
https://advancedfunctionalmedicine.com.au/b12-deficiency-and-mthfr/COMT is another interesting one where "This area of the brain is involved with personality, inhibition of behaviors, short-term memory, planning, abstract thinking, and emotion. COMT is also involved with metabolizing estrogens. COMT (-/-) individuals can usually break down these neurotransmitters efficiently, but COMT (+/+) individuals may have trouble breaking these chemicals down from impaired function of the enzyme. With a COMT + status, it has been clinically observed by physicians that people may have trouble with methyl donors. This can lead to irritability, hyperactivity, or abnormal behavior. They may also be more sensitive to pain."
CYP1B1 showed up in my detoxification panel as homozygous (red). Looking into it a bit further, it's responsible for the metabolism of steroids. So, perhaps the strong reaction to steroids could be down to the individual makeup of this gene? I'm not sure as I don't think I've had any steroids since my ventolin inhaler as a child. Homozygous or +/+ is apparently a fast metabolizer although I'm not 100% sure of all the factors influencing this. Some of the supplements in the article below might slow the enzyme activity as well. The Zyflamend seems interesting in reducing overall inflammation.
https://supplements.selfdecode.com/blog/cyp1b1/This is also a good link between drug interactions and methylation:
https://mthfrgenehealth.com/wp-content/uploads/2016/04/Drugs-medications-methylation-MTHFR.pdf
Maybe for you Sweetsixty - a link between epilepsy and MTHFR:
https://www.liebertpub.com/doi/abs/10.1089/neu.2011.1982?journalCode=neuLooking at the links, it does seem like the symptoms are still split between "psychiatric" and "physical." The only research paper I could find linking MTHFR and early childhood trauma was one that showed a connection between trauma, MTHFR C677T and an increased likelyhood of a major depressive disorder. I haven't found anything between trauma, MTHFR and an increased likelihood of physical problems. Although, it was implied in one article.
Interested to hear about others experiences with genetics and physical symptoms.